The Reliability Study of Ram BOP Seals of Temperature snubbing

In order to study the safety and reliability of the seal ram BOP, this article analyzes the structure and principles of ram BOP, draws the reason of seals failure by analyzing the forces of sealant core; uses accurate simulation on plastic core by ANSYS Software and then draws that morph mainly occurs in front of the plastic core. After the scene several simulation experiments, the damage is consistent with the results of finite element analysis

The Reliability Study of Ram BOP Seals of Temperature snubbing

In order to study the safety and reliability of the seal ram BOP, this article analyzes the structure and principles of ram BOP, draws the reason of seals failure by analyzing the forces of sealant core; uses accurate simulation on plastic core by ANSYS Software and then draws that morph mainly occurs in front of the plastic core. After the scene several simulation experiments, the damage is consistent with the results of finite element analysis

Lactobacillus plantarum

Constipation is a common clinical manifestation of digestive system disorders and occurs worldwide. This study investigated the ability of Lactobacillus plantarum KSFY06 (LP-KSFY06) to promote the action of geniposide in preventing montmorillonite-induced constipation in Kunming mice, with the aim of providing a successful solution. The effects of LP-KSFY06 and geniposide on constipation were measured, and the results showed that the protective effect of geniposide on constipation was enhanced by LP-KSFY06 and that the combination resulted in increased weight, moisture content, and particle number of feces. The first black stool defecation time was decreased from 182 min to 87 min, which clearly indicates that defecating difficulty was alleviated in constipated mice. The synergic intervention of LP-KSFY06 and geniposide (LP + G) assisted in maintaining the body weight of constipated mice. The LP + G intervention significantly increased serum levels of motilin (MTL, 167.8 pg/ml), acetylcholinesterase (AChE, 45.3 pg/ml), substance P (SP, 61.0 pg/ml), vasoactive intestinal peptide (VIP, 70.5 pg/ml), endothelin-1 (ET-1, 16.1 pg/ml), and gastrin (73.0 pg/ml) and remarkably decreased somatostatin (SS, 35.2 pg/ml) when compared to those indexes in the LP-KSFY06 group and geniposide group. The LP + G treatment also significantly increased the mRNA expression of cluster of differentiation 117 (c-Kit), stem cell factor (SCF), glial cell-derived neurotrophic factor (GDNF), and remarkably downregulated the expression of inducible nitric oxide synthase (iNOS), transient receptor potential vanilloid-1 (TRPV1), and cyclooxygenase-2 (COX-2). The experimental results showed that the combination treatment has the strongest prevention effect against constipation, and LP-KSFY06 promotes the ability of geniposide to prevent constipation. Therefore, LP-KSFY06 is a potential probiotic strain with the capacity to prevent montmorillonite-induced constipation

Lactobacillus plantarum KSFY06 and geniposide counteract montmorillonite-induced constipation in Kunming mice

Constipation is a common clinical manifestation of digestive system disorders and occurs worldwide. This study investigated the ability of Lactobacillus plantarum KSFY06 (LP-KSFY06) to promote the action of geniposide in preventing montmorillonite-induced constipation in Kunming mice, with the aim of providing a successful solution. The effects of LP-KSFY06 and geniposide on constipation were measured, and the results showed that the protective effect of geniposide on constipation was enhanced by LP-KSFY06 and that the combination resulted in increased weight, moisture content, and particle number of feces. The first black stool defecation time was decreased from 182 min to 87 min, which clearly indicates that defecating difficulty was alleviated in constipated mice. The synergic intervention of LP-KSFY06 and geniposide (LP + G) assisted in maintaining the body weight of constipated mice. The LP + G intervention significantly increased serum levels of motilin (MTL, 167.8 pg/ml), acetylcholinesterase (AChE, 45.3 pg/ml), substance P (SP, 61.0 pg/ml), vasoactive intestinal peptide (VIP, 70.5 pg/ml), endothelin-1 (ET-1, 16.1 pg/ml), and gastrin (73.0 pg/ml) and remarkably decreased somatostatin (SS, 35.2 pg/ml) when compared to those indexes in the LP-KSFY06 group and geniposide group. The LP + G treatment also significantly increased the mRNA expression of cluster of differentiation 117 (c-Kit), stem cell factor (SCF), glial cell-derived neurotrophic factor (GDNF), and remarkably downregulated the expression of inducible nitric oxide synthase (iNOS), transient receptor potential vanilloid-1 (TRPV1), and cyclooxygenase-2 (COX-2). The experimental results showed that the combination treatment has the strongest prevention effect against constipation, and LP-KSFY06 promotes the ability of geniposide to prevent constipation. Therefore, LP-KSFY06 is a potential probiotic strain with the capacity to prevent montmorillonite-induced constipation

Peano-hydraulically amplified self-healing electrostatic actuators based on a novel bilayer polymer shell for enhanced strain, load and rotary motion

The hydraulically amplified self-healing electrostatic actuator is an emerging driving component for soft robotics, which is composed of a flexible dielectric polymer shell that is partially covered by conductive electrodes and filled with a liquid dielectric. However, the low permittivity and dielectric strength of the polymer shell remain a challenge that limits the actuator performance. Herein, a Peano-hydraulically amplified self-healing electrostatic actuator is constructed by innovatively integrating a bilayer polymer shell for combined favorable properties of high dielectric strength, dielectric permittivity, and elastic modulus. Compared with a traditional single-layer shell actuator, the new bilayer actuator architecture generates an increased strain (164%) at 5 kV and improves load-bearing capability (620 mN) at 6 kV, thereby providing a significantly enhanced actuation performance. The new actuator is further applied in driving a ratchet system, which converts the reciprocating motion of the actuator into a rotating motion and a flexible output torque, in order to protect the rotating components from impact. The high strain and load characteristics of the bilayer configuration and the easy-to-deform characteristics of the new actuator design make it an attractive approach to fabricate complex geometries and achieve a variety of motion modes in soft systems